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what effect it would produce on various substances, or by observing that portions of the chloride had repeatedly become black, and inquiring into the circumstances. The effect of the urali poison might have become known either by administering it to animals, or by examining how it happened that the wounds which the Indians of Guiana inflict with their arrows prove so uniformly mortal. Now it is manifest from the mere statement of the examples, without any theoretical discussion, that artificial experimentation is applicable only to the former of these modes of investigation. We can take a cause, and try what it will produce: but we cannot take an effect, and try what it will be produced by. We can only watch till we see it produced, or are enabled to produce it by accident.

This would be of little importance, if it always depended on our choice from which of the two ends of the sequence we would undertake our inquiries. But we have seldom any option. As we can only travel from the known to the unknown, we are obliged to commence at whichever end we are best acquainted with. If the agent is more familiar to us than its effects, we watch for, or contrive, instances of the agent, under such varieties of circumstances as are open to us, and observe the result. If, on the contrary, the conditions on which a phenomenon depends are obscure, but the phenomenon itself familiar, we must commence our inquiry from the effect. If we are struck with the fact that chloride of silver has been blackened, and have no suspicion of the cause, we have no resource but to compare instances in which the fact has chanced to occur, until by that comparison we discover that in all those instances the substances had been exposed to light. If we knew nothing of the Indian arrows but their fatal effect, accident alone could turn our attention to experiments on the urali; in the regular course of investigation, we could only inquire, or try to observe, what had been done to the arrows in particular instances.

Wherever, having nothing to guide us to the cause, we are obliged to set out from the effect, and to apply the rule of varying the circumstances to the consequents, not the antecedents, we are necessarily destitute of the resource of artificial experimentation. We cannot, at our choice, obtain consequents, as we can antecedents, under any set of circumstances compatible with their nature. There are no means of producing effects but through their causes, and by the supposition the causes of the effect in question are not known to us. We have therefore no expedient but to study it where it offers itself spontaneously. If nature happens to present us with instances sufficiently varied in their circumstances, and if we are able to discover, either among the proximate antecedents or among some other order of antecedents, something which is always found when the effect is found, however various the circumstances, and never found when it is not; we may discover, by mere observation without experiment, a real uniformity in nature.

But though this is certainly the most favourable case for sciences of pure observation, as contrasted with those in which artificial experiments are possible, there is in reality no case which more strikingly illustrates the inherent imperfection of direct induction when not founded on experimentation. Suppose that, by a comparison of cases of the effect, we have found an antecedent which appears to be, and perhaps is, invariably connected with it: we have not yet proved that antecedent to be the cause, until we have reversed the process, and produced the effect by means of that antecedent. If we can produce the antecedent artificially, and if, when we do so, the effect follows, the induction is complete; that antecedent is the cause of that consequent.[32] But we have then added the evidence of experiment to that of simple observation. Until we had done so, we had only proved invariable antecedence within the limits of experience, but not unconditional antecedence, or causation. Until it had been shown by the actual production of the antecedent under known circumstances, and the occurrence thereupon of the consequent, that the antecedent was really the condition on which it depended; the uniformity of succession which was proved to exist between them might, for aught we knew, be (like the succession of day and night) not a case of causation at all; both antecedent and consequent might be successive stages of the effect of an ulterior cause. Observation, in short, without experiment (supposing no aid from deduction) can ascertain sequences and coexistences, but cannot prove causation.

In order to see these remarks verified by the actual state of the sciences, we have only to think of the condition of natural history. In zoology, for example, there is an immense number of uniformities ascertained, some of coexistence, others of succession, to many of which, notwithstanding considerable variations of the attendant circumstances, we know not any exception: but the antecedents, for the most part, are such as we cannot artificially produce; or if we can, it is only by setting in motion the exact process by which nature produces them; and this being to us a mysterious process, of which the main circumstances are not only unknown but unobservable, we do not succeed in obtaining the antecedents under known circumstances. What is the result? That on this vast subject, which affords so much and such varied scope for observation, we have made most scanty progress in ascertaining any laws of causation. We know not with certainty, in the case of most of the phenomena that we find conjoined, which is the condition of the other; which is cause, and which effect, or whether either of them is so, or they are not rather conjunct effects of causes yet to be discovered, complex results of laws hitherto unknown.

Although some of the foregoing observations may be, in technical strictness of arrangement, premature in this place, it seemed that a few general remarks on the difference between sciences of mere observation and sciences of experimentation, and the extreme disadvantage under which directly inductive inquiry is necessarily carried on in the former, were the best preparation for discussing the methods of direct induction; a preparation rendering superfluous much that must otherwise have been introduced, with some inconvenience, into the heart of that discussion. To the consideration of these methods we now proceed.

CHAPTER VIII.
OF THE FOUR METHODS OF EXPERIMENTAL INQUIRY.

§ 1. The simplest and most obvious modes of singling out from among the circumstances which precede or follow a phenomenon, those with which it is really connected by an invariable law, are two in number. One is, by comparing together different instances in which the phenomenon occurs. The other is, by comparing instances in which the phenomenon does occur, with instances in other respects similar in which it does not. These two methods may be respectively denominated, the Method of Agreement, and the Method of Difference.

In illustrating these methods, it will be necessary to bear in mind the twofold character of inquiries into the laws of phenomena; which may be either inquiries into the cause of a given effect, or into the effects or properties of a given cause. We shall consider the methods in their application to either order of investigation, and shall draw our examples equally from both.

We shall denote antecedents by the large letters of the alphabet, and the consequents corresponding to them by the small. Let A, then, be an agent or cause, and let the object of our inquiry be to ascertain what are the effects of this cause. If we can either find, or produce, the agent A in such varieties of circumstances, that the different cases have no circumstance in common except A; then whatever effect we find to be produced in all our trials, is indicated as the effect of A. Suppose, for example, that A is tried along with B and C, and that the effect is a b c; and suppose that A is next tried with D and E, but without B and C, and that the effect is a d e. Then we may reason thus: b and c are not effects of A, for they were not produced by it in the second experiment; nor are d and e, for they were not produced in the first. Whatever is really the effect of A must have been produced in both instances; now this condition is fulfilled by no circumstance except a. The phenomenon a cannot have been the effect of B or C, since it was produced where they were not; nor of D or E, since it was produced where they were not. Therefore it is the effect of A.

For example, let the antecedent A be the contact of an alkaline substance and an oil. This combination being tried under several varieties of circumstances, resembling each other in nothing else, the results agree in the production of a greasy and detersive or saponaceous substance: it is therefore concluded that the combination of an oil and an alkali causes the production of a soap. It is thus we inquire, by the Method of Agreement, into the effect of a given cause.

In a similar manner we may inquire into the cause of a given effect. Let a be the effect. Here, as shown in the last chapter, we have only the resource of observation without experiment: we cannot take a phenomenon of which we know not the origin, and try to find its mode of production by producing it: if we succeeded in such a random trial it could only be by accident. But if we can observe a in two different combinations, a b c, and a d e; and if we know, or can discover, that the antecedent circumstances in these cases respectively were A B C and A D E; we may conclude by a reasoning similar to that in the preceding example, that A is the antecedent connected with the consequent a by a law of causation. B and C, we may say, cannot be causes of a, since on its second occurrence they were not present; nor are D and E, for they were not present on its first occurrence. A, alone of the five circumstances, was found among the antecedents of a in both instances.

For example, let the effect a be crystallization. We compare instances in which bodies are known to assume crystalline structure, but which have no other point of agreement; and we find them to have one, and as far as we can observe, only one, antecedent in common: the deposition of a solid matter from a liquid state, either a state of fusion or of solution. We conclude, therefore, that the solidification of a substance from a liquid state is an invariable antecedent of its crystallization.

In this example we may go farther, and say, it is not only the invariable antecedent but the cause; or at least the proximate event which completes the cause. For in this case we are able, after detecting the antecedent A, to produce it artificially, and by finding that a follows it, verify the result of our induction. The importance of thus reversing the proof was strikingly manifested when by keeping a phial of water charged with siliceous particles undisturbed for years, a chemist (I believe Dr. Wollaston) succeeded in obtaining crystals of quartz: and in the equally interesting experiment in which Sir James Hall produced artificial marble, by the cooling of its materials from fusion under immense pressure: two admirable examples of the light which may be thrown upon the most secret processes of nature by well-contrived interrogation of her.

But if we cannot artificially

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