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the fingers the incisions should be made in the middle line, and in the palm they should be made over the metacarpal bones to avoid the digital vessels and nerves. If pus has spread under the transverse carpal ligament, the incision must be made above the wrist. Passive movements and massage must be commenced as early as possible and be perseveringly employed to diminish the formation of adhesions and resulting stiffness.

Subperiosteal Whitlow.—This form is usually an extension of the subcutaneous or of the thecal variety, but in some cases the inflammation begins in the periosteum—usually of the terminal phalanx. It may lead to necrosis of a portion or even of the entire phalanx. This is usually recognised by the persistence of suppuration long after the acute symptoms have passed off, and by feeling bare bone with the probe. In such cases one or more of the joints are usually implicated also, and lateral mobility and grating may be elicited. Recovery does not take place until the dead bone is removed, and the usefulness of the finger is often seriously impaired by fibrous or bony ankylosis of the interphalangeal joints. This may render amputation advisable when a stiff finger is likely to interfere with the patient's occupation.

Suppurative Cellulitis in Different Situations

Cellulitis of the forearm is usually a sequel to one of the deeper varieties of whitlow.

In the region of the elbow-joint, cellulitis is common around the olecranon. It may originate as an inflammation of the olecranon bursa, or may invade the bursa secondarily. In exceptional cases the elbow-joint is also involved.

Cellulitis of the axilla may originate in suppuration in the lymph glands, following an infected wound of the hand, or it may spread from a septic wound on the chest wall or in the neck. In some cases it is impossible to discover the primary seat of infection. A firm, brawny swelling forms in the armpit and extends on to the chest wall. It is attended with great pain, which is increased on moving the arm, and there is marked constitutional disturbance. When suppuration occurs, its spread is limited by the attachments of the axillary fascia, and the pus tends to burrow on to the chest wall beneath the pectoral muscles, and upwards towards the shoulder-joint, which may become infected. When the pus forms in the axillary space, the treatment consists in making free incisions, which should be placed on the thoracic side of the axilla to avoid the axillary vessels and nerves. If the pus spreads on to the chest wall, the abscess should be opened below the clavicle by Hilton's method, and a counter opening may be made in the axilla.

Cellulitis of the sole of the foot may follow whitlow of the toes.

In the region of the ankle cellulitis is not common; but around the knee it frequently occurs in relation to the prepatellar bursa and to the popliteal lymph glands, and may endanger the knee-joint. It is also met with in the groin following on inflammation and suppuration of the inguinal glands, and cases are recorded in which the sloughing process has implicated the femoral vessels and led to secondary hæmorrhage.

Cellulitis of the scalp, orbit, neck, pelvis, and perineum will be considered with the diseases of these regions.

Chronic Suppuration

While it is true that a chronic pyogenic abscess is sometimes met with—for example, in the breast and in the marrow of long bones—in the great majority of instances the formation of a chronic or cold abscess is the result of the action of the tubercle bacillus. It is therefore more convenient to study this form of suppuration with tuberculosis (p. 139).

Sinus and Fistula

Sinus.—A sinus is a track leading from a focus of suppuration to a cutaneous or mucous surface. It usually represents the path by which the discharge escapes from an abscess cavity that has been prevented from closing completely, either from mechanical causes or from the persistent formation of discharge which must find an exit. A sinus is lined by granulation tissue, and when it is of long standing the opening may be dragged below the level of the surrounding skin by contraction of the scar tissue around it. As a sinus will persist until the obstacle to closure of the original abscess is removed, it is necessary that this should be sought for. It may be a foreign body, such as a piece of dead bone, an infected ligature, or a bullet, acting mechanically or by keeping up discharge, and if the body is removed the sinus usually heals. The presence of a foreign body is often suggested by a mass of redundant granulations at the mouth of the sinus. If a sinus passes through a muscle, the repeated contractions tend to prevent healing until the muscle is kept at rest by a splint, or put out of action by division of its fibres. The sinuses associated with empyema are prevented from healing by the rigidity of the chest wall, and will only close after an operation which admits of the cavity being obliterated. In any case it is necessary to disinfect the track, and, it may be, to remove the unhealthy granulations lining it, by means of the sharp spoon, or to excise it bodily. To encourage healing from the bottom the cavity should be packed with bismuth or iodoform gauze. The healing of long and tortuous sinuses is often hastened by the injection of Beck's bismuth paste (p. 145). If disfigurement is likely to follow from cicatricial contraction—for example, in a sinus over the lower jaw associated with a carious tooth—the sinus should be excised and the raw surfaces approximated with stitches.

The tuberculous sinus is described under Tuberculosis.

A fistula is an abnormal canal passing from a mucous surface to the skin or to another mucous surface. Fistulæ resulting from suppuration usually occur near the natural openings of mucous canals—for example, on the cheek, as a salivary fistula; beside the inner angle of the eye, as a lacrymal fistula; near the ear, as a mastoid fistula; or close to the anus, as a fistula-in-ano. Intestinal fistulæ are sometimes met with in the abdominal wall after strangulated hernia, operations for appendicitis, tuberculous peritonitis, and other conditions. In the perineum, fistulæ frequently complicate stricture of the urethra.

Fistulæ also occur between the bladder and vagina (vesico-vaginal fistula), or between the bladder and the rectum (recto-vesical fistula).

The treatment of these various forms of fistula will be described in the sections dealing with the regions in which they occur.

Congenital fistulæ, such as occur in the neck from imperfect closure of branchial clefts, or in the abdomen from unobliterated fœtal ducts such as the urachus or Meckel's diverticulum, will be described in their proper places.

Constitutional Manifestations of Pyogenic Infection

We have here to consider under the terms Sapræmia, Septicæmia, and Pyæmia certain general effects of pyogenic infection, which, although their clinical manifestations may vary, are all associated with the action of the same forms of bacteria. They may occur separately or in combination, or one may follow on and merge into another.

Sapræmia, or septic intoxication, is the name applied to a form of poisoning resulting from the absorption into the blood of the toxic products of pyogenic bacteria. These products, which are of the nature of alkaloids, act immediately on their entrance into the circulation, and produce effects in direct proportion to the amount absorbed. As the toxins are gradually eliminated from the body the symptoms abate, and if no more are introduced they disappear. Sapræmia in these respects, therefore, is comparable to poisoning by any other form of alkaloid, such as strychnin or morphin.

Clinical Features.—The symptoms of sapræmia seldom manifest themselves within twenty-four hours of an operation or injury, because it takes some time for the bacteria to produce a sufficient dose of their poisons. The onset of the condition is marked by a feeling of chilliness, sometimes amounting to a rigor, and a rise of temperature to 102°, 103°, or 104° F., with morning remissions (Fig. 10). The heart's action is markedly depressed, and the pulse is soft and compressible. The appetite is lost, the tongue dry and covered with a thin brownish-red fur, so that it has the appearance of “dried beef.” The urine is scanty and loaded with urates. In severe cases diarrhĹ“a and vomiting of dark coffee-ground material are often prominent features. Death is usually impending when the skin becomes cold and clammy, the mucous membranes livid, the pulse feeble and fluttering, the discharges involuntary, and when a low form of muttering delirium is present.

Fig. 10.—Charts of Acute sapræmia from (a) case of crushed foot, and (b) case of incomplete abortion.

Fig. 10.—Charts of Acute sapræmia from (a) case of crushed foot, and (b) case of incomplete abortion.

A local form of septic infection is always present—it may be an abscess, an infected compound fracture, or an infection of the cavity of the uterus, for example, from a retained portion of placenta.

Treatment.—The first indication is the immediate and complete removal of the infected material. The wound must be freely opened, all blood-clot, discharge, or necrosed tissue removed, and the area disinfected by washing with sterilised salt solution, peroxide of hydrogen, or eusol. Stronger lotions are to be avoided as being likely to depress the tissues, and so interfere with protective phagocytosis. On account of its power of neutralising toxins, iodoform is useful in these cases, and is best employed by packing the wound with iodoform gauze, and treating it by the open method, if this is possible.

The general treatment is carried out on the same lines as for other infective conditions.

Chronic sapræmia or Hectic Fever.—Hectic fever differs from acute sapræmia merely in degree. It usually occurs in connection with tuberculous conditions, such as bone or joint disease, psoas abscess, or empyema, which have opened externally, and have thereby become infected with pyogenic organisms. It is gradual in its development, and is of a mild type throughout.

Fig. 11.—Chart of Hectic Fever.

Fig. 11.—Chart of Hectic Fever.

The pulse is small, feeble, and compressible, and the temperature rises in the afternoon or evening to 102° or 103° F. (Fig. 11), the cheeks becoming characteristically flushed. In the early morning the temperature falls to normal or below it, and the patient breaks into a profuse perspiration, which leaves him pale, weak, and exhausted. He becomes rapidly and markedly emaciated, even although in some cases the appetite remains good and is even voracious.

The poisons circulating in the blood produce waxy degeneration in certain viscera, notably the liver, spleen, kidneys, and intestines. The process begins in the arterial walls, and spreads thence to the connective-tissue structures, causing marked enlargement of the affected organs. Albuminuria, ascites, œdema of the lower limbs, clubbing of the fingers, and diarrhœa are among the most prominent symptoms of this condition.

The prognosis in hectic fever depends on the completeness with which the further absorption of toxins can be prevented. In many cases this can only be effected by an operation which provides for free drainage, and, if possible, the removal of infected tissues. The resulting wound is best treated by the open method. Even advanced waxy degeneration does not contra-indicate this line of treatment, as the diseased organs usually recover if the focus from which absorption of toxic material is taking place is completely eradicated.

Fig. 12.—Chart of case of Septicæmia followed by Pyæmia.

Fig. 12.—Chart of case of Septicæmia followed by Pyæmia.

Septicæmia.—This form of blood-poisoning is the result of the action of pyogenic bacteria, which not only produce their toxins at the primary seat of infection, but themselves enter the blood-stream and are carried to other parts, where they settle and produce further effects.

Clinical Features.—There may be an incubation period of some hours between the infection and the first manifestation of acute septicæmia. In such conditions as acute

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